Characterization of cardiac metabolism in iPSC-derived cardiomyocytes: lessons from maturation and disease modeling.

ABSTRACT:

Background

Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have emerged as a powerful tool for disease modeling, though their immature nature currently limits translation into clinical practice. Maturation strategies increasingly pay attention to cardiac metabolism because of its pivotal role in cardiomyocyte development and function. Moreover, aberrances in cardiac metabolism are central to the pathogenesis of cardiac disease. Thus, proper modeling of human cardiac disease warrants careful characterization of the metabolic properties of iPSC-CMs.

Methods

Here, we examined the effect of maturation protocols on healthy iPSC-CMs applied in 23 studies and compared fold changes in functional metabolic characteristics to assess the level of maturation. In addition

SUBMITTER: Vuckovic S 

PROVIDER: S-EPMC9308297 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature