Ventilator-induced lung injury results in oxidative stress response and mitochondrial swelling in a mouse model.

ABSTRACT:

Background

Mechanical ventilation is a life-saving therapy for critically ill patients, providing rest to the respiratory muscles and facilitating gas exchange in the lungs. Ventilator-induced lung injury (VILI) is an unfortunate side effect of mechanical ventilation that may lead to serious consequences for the patient and increase mortality. The four main injury mechanisms associated with VILI are: baro/volutrauma caused by overstretching the lung tissues; atelectrauma, caused by repeated opening and closing of the alveoli resulting in shear stress; oxygen toxicity due to use of high ratio of oxygen in inspired air, causing formation of free radicals; and biotrauma, the resulting biological response to tissue injury, that leads to a cascade of events due to excessive inflammatory

SUBMITTER: Joelsson JP 

PROVIDER: S-EPMC9308307 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature