Effect of acute ketosis on lipid profile in prediabetes: findings from a cross-over randomized controlled trial.

ABSTRACT:

Background

Ketone monoester β-hydroxybutyrate (KEβHB) ingestion has emerged as an effective method of inducing acute ketosis. Although evidence suggests that KEβHB can offer several therapeutic benefits, whether KEβHB affects lipid profile is still unknown.

Aims

The primary aim was to study the effect of KEβHB on plasma lipid profile in individuals with prediabetes. The secondary aim was to investigate the role of saturated fat intake in that effect.

Methods

This study was a randomized controlled trial with cross-over design. Following an overnight fast, 18 adults (six women and 12 men) with prediabetes (diagnosed based on the American Diabetes Association criteria) ingested a single dose of KEβHB drink or placebo drink. Blood samples were collected every 30 min, from

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9308353 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature