Abnormal paraoxonase-1 (PON1) enzyme activity in idiopathic inflammatory myopathies.

ABSTRACT:

Objectives

Patients with idiopathic inflammatory myopathies (IIM) have severe vascular involvement, which contributes to disease morbidity and mortality. Paraoxonase-1 (PON1) is a high-density lipoprotein (HDL) associated protein that protects the vascular endothelium from oxidative injury and damage. The current work assessed the functional and genetic determinants of PON1 activity in IIM patients.

Methods

A total of 184 IIM patients and 112 healthy controls (HC) were included. PON1 enzyme activity was assessed by paraoxonase, arylesterase and lactonase assays, and the Q192R PON1 single nucleotide polymorphism (SNP) was analysed. Multivariate regression models examined associations of PON1 activity with IIM diagnosis and myositis disease outcomes.

Results

The arylest

SUBMITTER: Bae SS 

PROVIDER: S-EPMC9308379 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature