Effect of leukoreduction on inflammation in critically ill dogs receiving red blood cell transfusions: A randomized blinded controlled clinical trial.

ABSTRACT:

Background

Prestorage leukoreduction of red blood cell (RBC) bags prevents accumulation of pro-inflammatory mediators and experimentally attenuates post-transfusion inflammation in healthy dogs. However, the effect of leukoreduction on post-transfusion inflammation in critically ill dogs is unclear.

Hypothesis

Dogs transfused with leukoreduced (LR) RBC will have lower concentrations of leukocytes, interleukin (IL)-6, IL-8, monocyte chemoattractant protein-1 (MCP-1), and C-reactive protein (CRP) within 24 hours of post-transfusion compared to dogs transfused with nonleukoreduced (NLR) RBC.

Animals

Sixty-one RBC-transfused dogs (LR = 34, NLR = 27).

Methods

Randomized, blinded, controlled preliminary clinical trial. Blood bag processing was randomized to create id

SUBMITTER: Claus MA 

PROVIDER: S-EPMC9308429 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature