The cannabinoid receptors system in horses: Tissue distribution and cellular identification in skin.

ABSTRACT:

Background

The endocannabinoid system (ECS) is composed of cannabinoid receptors type 1 (CBR1) and type 2 (CBR2), cannabinoid-based ligands (endogenous chemically synthesized phytocannabinoids), and endogenous enzymes controlling their concentrations. Cannabinoid receptors (CBRs) have been identified in invertebrates and in almost all vertebrate species in the central and peripheral nervous system as well as in immune cells, where they control neuroimmune homeostasis. In humans, rodents, dogs, and cats, CBRs expression has been confirmed in the skin, and their expression and tissue distribution become disordered in pathological conditions. Cannabinoid receptors may be a possible therapeutic target in skin diseases.

Objectives

To characterize the distribution and cellular exp

SUBMITTER: Kupczyk P 

PROVIDER: S-EPMC9308437 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature