Dataset Information

Serial evaluation of thoracic radiographs and acute phase proteins in dogs with pneumonia.

ABSTRACT:

Background

Acute phase proteins (APP) may guide treatment of pneumonia in dogs but correlations with radiographic abnormalities are poorly characterized.

Objectives

Develop a thoracic radiographic severity scoring system (TRSS), assess correlation of radiographic changes with APP concentrations, and compare time to APP and radiograph normalization with duration of antimicrobials treatment.

Animals

Sixteen client-owned dogs, 12 with aspiration pneumonia, and 4 with community-acquired pneumonia.

Methods

Concentrations of C-reactive protein (CRP), serum amyloid A (SAA), and haptoglobin were measured on days 1, 3, 7, 14, 28, and 60 and orthogonal 2-view thoracic radiographs were obtained on days 1, 7, 14, 28, and 60. Treatment was clinician-guided and blinded to APP concentrations. Radiographic severity scores were assigned by blinded, randomized retrospective review by 2 board-certified radiologists with arbitration by a third radiologist.

Results

Median (interquartile range [IQR]) time to normalization of CRP (7 days [7-14]) and SAA concentrations (7 days [7-14]) were shorter than antimicrobial treatment duration (17.5 days [14.5-33.5]; P = .001 and .002, respectively) and TRSS normalization (14 days [8.8-52], P = .02 and .02, respectively). The CRP and SAA concentrations were positively correlated with TRSS (CRP r_s , 0.643; SAA r_s , 0.634; both P < .0001). Both CRP and SAA identified normal thoracic radiographs area under the curve (AUC) 0.873 and 0.817, respectively, both P < .0001. Interobserver agreement for TRSS assignment was moderate (κ, .499; P < .0001).

Conclusion and clinical importance

Concentrations of CRP and SAA normalized before radiographic resolution and before clinicians discontinued antimicrobial treatment. The CRP and SAA concentrations may guide duration of antimicrobial treatment for dogs with pneumonia.

SUBMITTER: Menard J

PROVIDER: S-EPMC9308444 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Publications

Serial evaluation of thoracic radiographs and acute phase proteins in dogs with pneumonia.

Menard Julie J Porter Ian I Lerer Assaf A Robbins Sarah S Johnson Philippa J PJ Goggs Robert R

Journal of veterinary internal medicine 20220526 4

<h4>Background</h4>Acute phase proteins (APP) may guide treatment of pneumonia in dogs but correlations with radiographic abnormalities are poorly characterized.<h4>Objectives</h4>Develop a thoracic radiographic severity scoring system (TRSS), assess correlation of radiographic changes with APP concentrations, and compare time to APP and radiograph normalization with duration of antimicrobials treatment.<h4>Animals</h4>Sixteen client-owned dogs, 12 with aspiration pneumonia, and 4 with community ...[more]

PMID: 35616241

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Dataset Information

Serial evaluation of thoracic radiographs and acute phase proteins in dogs with pneumonia.

Background

Objectives

Animals

Methods

Results

Conclusion and clinical importance

Publications

Serial evaluation of thoracic radiographs and acute phase proteins in dogs with pneumonia.

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