Escherichia coli transcription factors of unknown function: sequence features and possible evolutionary relationships.

ABSTRACT: Organisms need mechanisms to perceive the environment and respond accordingly to environmental changes or the presence of hazards. Transcription factors (TFs) are required for cells to respond to the environment by controlling the expression of genes needed. Escherichia coli has been the model bacterium for many decades, and still, there are features embedded in its genome that remain unstudied. To date, 58 TFs remain poorly characterized, although their binding sites have been experimentally determined. This study showed that these TFs have sequence variation at the third codon position G+C content but maintain the same Codon Adaptation Index (CAI) trend as annotated functional transcription factors. Most of these transcription factors are in areas of the genome where abundant repe

SUBMITTER: Duarte-Velazquez I 

PROVIDER: S-EPMC9308461 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature