Genomic Analysis of Abnormal DNAM Methylation in Parathyroid Tumors.

ABSTRACT:

Background

Parathyroid tumors are common endocrine neoplasias associated with primary hyperparathyroidism. Although numerous studies have studied the subject, the predictive value of gene biomarkers nevertheless remains low.

Methods

In this study, we performed genomic analysis of abnormal DNA methylation in parathyroid tumors. After data preprocessing, differentially methylated genes were extracted from patients with parathyroid tumors by using t-tests.

Results

After refinement of the basic differential methylation, 28241 unique CpGs (634 genes) were identified to be methylated. The methylated genes were primarily involved in 7 GO terms, and the top 3 terms were associated with cyst morphogenesis, ion transport, and GTPase signal. Following pathway enrichment a

SUBMITTER: Li Q 

PROVIDER: S-EPMC9308548 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature