Cortical abnormalities of synaptic vesicle protein 2A in focal cortical dysplasia type II identified in vivo with ¹⁸F-SynVesT-1 positron emission tomography imaging.

ABSTRACT:

Purpose

The loss of synaptic vesicle glycoprotein 2A (SV2A) is well established as the major correlate of epileptogenesis in focal cortical dysplasia type II (FCD II), but this has not been directly tested in vivo. In this positron emission tomography (PET) study with the new tracer ¹⁸F-SynVesT-1, we evaluated SV2A abnormalities in patients with FCD II and compared the pattern to ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG).

Methods

Sixteen patients with proven FCD II and 16 healthy controls were recruited. All FCD II patients underwent magnetic resonance imaging (MRI) and static PET imaging with both ¹⁸F-SynVesT-1 and ¹⁸F-FDG, while the controls underwent MRI and PET with only ¹⁸F-SynVesT-1. Visual assessment of PET imag

SUBMITTER: Tang Y 

PROVIDER: S-EPMC9308579 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature