LncRNA ENSMUST_147219 mediates the progression of ischemic acute kidney injury by targeting the miR-221-5p/IRF6 axis.
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ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC9308590 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
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LncRNA ENSMUST_147219 mediates the progression of ischemic acute kidney injury by targeting the miR-221-5p/IRF6 axis.
Liu Jing J Li Xiaozhou X Yang Jurong J Zhang Dongshan D
Apoptosis : an international journal on programmed cell death 20220526 7-8
Although previous studies have revealed that long noncoding RNAs (lncRNAs) regulate the progression of ischemic acute kidney injury (AKI), the exact role and mechanism of lncRNA ENSMUST_147219 in ischemic AKI are not clear. In the present study, lncRNA ENSMUST_147219 was induced by ischemic injury in vitro and in vivo. Functionally, lncRNA ENSMUST_147219 mediated apoptosis in mouse proximal tubule-derived cell line (BUMPT). Mechanistically, lncRNA ENSMUST_147219 sponged the microRNA (miR)-221-5p ...[more]
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