Targeting Adiponectin Receptor 1 Phosphorylation Against Ischemic Heart Failure.

ABSTRACT:

Background

Despite significantly reduced acute myocardial infarction (MI) mortality in recent years, ischemic heart failure continues to escalate. Therapeutic interventions effectively reversing pathological remodeling are an urgent unmet medical need. We recently demonstrated that AdipoR1 (APN [adiponectin] receptor 1) phosphorylation by GRK2 (G-protein-coupled receptor kinase 2) contributes to maladaptive remodeling in the ischemic heart. The current study clarified the underlying mechanisms leading to AdipoR1 phosphorylative desensitization and investigated whether blocking AdipoR1 phosphorylation may restore its protective signaling, reversing post-MI remodeling.

Methods

Specific sites and underlying molecular mechanisms responsible for AdipoR1 phosphorylative desensitiz

SUBMITTER: Zhu D 

PROVIDER: S-EPMC9308652 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature