Endothelial Cells Induced Progenitors Into Brown Fat to Reduce Atherosclerosis.

ABSTRACT:

Background

Insulin resistance (IR) can increase atherosclerotic and cardiovascular risk by inducing endothelial dysfunction, decreasing nitric oxide (NO) production, and accelerating arterial inflammation. The aim is to determine the mechanism by which insulin action and NO production in endothelial cells can improve systemic bioenergetics and decrease atherosclerosis via differentiation of perivascular progenitor cells (PPCs) into brown adipocytes (BAT).

Methods

Studies used various endothelial transgenic and deletion mutant ApoE^-/- mice of insulin receptors, eNOS (endothelial NO synthase) and ETBR (endothelin receptor type B) receptors for assessments of atherosclerosis. Cells were isolated from perivascular fat and micro-vessels for studies on differenti

SUBMITTER: Park K 

PROVIDER: S-EPMC9308716 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature