Epicardial HDAC3 Promotes Myocardial Growth Through a Novel MicroRNA Pathway.

ABSTRACT:

Background

Establishment of the myocardial wall requires proper growth cues from nonmyocardial tissues. During heart development, the epicardium and epicardium-derived cells instruct myocardial growth by secreting essential factors including FGF (fibroblast growth factor) 9 and IGF (insulin-like growth factor) 2. However, it is poorly understood how the epicardial secreted factors are regulated, in particular by chromatin modifications for myocardial formation. The current study is to investigate whether and how HDAC (histone deacetylase) 3 in the developing epicardium regulates myocardial growth.

Methods

Various cellular and mouse models in conjunction with biochemical and molecular tools were employed to study the role of HDAC3 in the developing epicardium.

Results

SUBMITTER: Jang J 

PROVIDER: S-EPMC9308743 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature