A polygenic score indexing a DRD2-related co-expression network is associated with striatal dopamine function.

ABSTRACT: The D2 dopamine receptor (D2R) is the primary site of the therapeutic action of antipsychotics and is involved in essential brain functions relevant to schizophrenia, such as attention, memory, motivation, and emotion processing. Moreover, the gene coding for D2R (DRD2) has been associated with schizophrenia at a genome-wide level. Recent studies have shown that a polygenic co-expression index (PCI) predicting the brain-specific expression of a network of genes co-expressed with DRD2 was associated with response to antipsychotics, brain function during working memory in patients with schizophrenia, and with the modulation of prefrontal cortex activity after pharmacological stimulation of D2 receptors. We aimed to investigate the relationship between the DRD2 gene network and in vivo striat

SUBMITTER: D'Ambrosio E 

PROVIDER: S-EPMC9308811 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature