Acute kidney injury associated to COVID-19 leads to a strong unbalance of circulant immune mediators.

ABSTRACT:

Background

Severe cases of coronavirus disease 2019 (COVID-19) have increased risk for acute kidney injury (AKI). The exacerbation of the immune response seems to contribute to AKI development, but the immunopathological process is not completely understood.

Objectives

To analyze levels of circulant immune mediators in COVID-19 patients evolving with or without AKI. We have also investigated possible associations of these mediators with viral load and clinical outcomes.

Methods

This is a longitudinal study performed with hospitalized patients with moderate to severe COVID-19. Serum levels of 27 immune mediators were measured by a multiplex immunoassay. Data were analyzed at two timepoints during the follow-up: within the first 13 days of the disease onset (early sampl

SUBMITTER: Medeiros T 

PROVIDER: S-EPMC9309102 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature