Interleukin-8 and depressive responses to an inflammatory challenge: secondary analysis of a randomized controlled trial.

ABSTRACT: Emerging evidence suggests that interleukin (IL)-8 has a protective role in the context of depression. Higher levels of IL-8 are associated with lower depressive symptom severity among depressed patients, and treatment-related increases in IL-8 correlate with a positive response in depressed patients. This study (a secondary analysis of a completed randomized controlled trial) aimed to examine whether higher levels of IL-8 mitigate increases in depressed mood in response to an experimental model of inflammation induced depression. Given epidemiologic relationships identified between IL-6, tumor necrosis factor (TNF)- α, and subsequent depression, levels of these pro-inflammatory cytokines were also explored as potential moderators of depressed mood response to endotoxin. Secondary analyses

SUBMITTER: Kruse JL 

PROVIDER: S-EPMC9309160 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature