CARs-DB: A Database of Cryptic Amyloidogenic Regions in Intrinsically Disordered Proteins.

ABSTRACT: Proteome-wide analyses suggest that most globular proteins contain at least one amyloidogenic region, whereas these aggregation-prone segments are thought to be underrepresented in intrinsically disordered proteins (IDPs). In recent work, we reported that intrinsically disordered regions (IDRs) indeed sustain a significant amyloid load in the form of cryptic amyloidogenic regions (CARs). CARs are widespread in IDRs, but they are necessarily exposed to solvent, and thus they should be more polar and have a milder aggregation potential than conventional amyloid regions protected inside globular proteins. CARs are connected with IDPs function and, in particular, with the establishment of protein-protein interactions through their IDRs. However, their presence also appears associated with path

SUBMITTER: Pintado-Grima C 

PROVIDER: S-EPMC9309178 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature