Timing evolution of lobular breast cancer through phylogenetic analysis.

ABSTRACT:

Background

Late distant recurrence is a challenge for the treatment of invasive lobular carcinoma (ILC) of the breast. Despite in-depth characterisation of primary ILC, the molecular landscape of metastatic ILC is still only partially understood.

Methods

We retrospectively identified 38 ILC patients from the tissue banks of six European institutions. DNA extracted from patient matched primary and metastatic FFPE tissue blocks was whole genome sequenced to compute somatic copy number aberrations. This, in turn, was used to infer the evolutionary history of these patients.

Findings

The data show different metastatic seeding patterns, with both an early and late divergence of the metastatic lineage observed in ILC. Additionally, cascading dissemination from a metastatic

SUBMITTER: Fimereli D 

PROVIDER: S-EPMC9309404 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature