Contribution of joint tissue properties to load-induced osteoarthritis.

ABSTRACT:

Objective

Clinical evidence suggests that abnormal mechanical forces play a major role in the initiation and progression of osteoarthritis (OA). However, few studies have examined the mechanical environment that leads to disease. Thus, using a mouse tibial loading model, we quantified the cartilage contact stresses and examined the effects of altering tissue material properties on joint stresses during loading.

Design

Using a discrete element model (DEA) in conjunction with joint kinematics data from a murine knee joint compression model, the magnitude and distribution of contact stresses in the tibial cartilage during joint loading were quantified at levels ranging from 0 to 9 N in 1 N increments. In addition, a simplified finite element (FEA) contact model was developed to

SUBMITTER: Ayobami OO 

PROVIDER: S-EPMC9309407 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature