Susceptibility Genes and HLA for Cold Medicine-Related SJS/TEN with SOC.

ABSTRACT: We investigated the genetic predisposition for the pathogenesis of Stevens-Johnson syndrome/epidermal necrolysis with severe ocular complications (SJS/TEN with SOC). Cold medicines (CMs) including multi-ingredient cold-medications and non-steroidal anti-inflammatory drugs (NSAIDs) were implicated in the development of SJS/TEN with SOC. Studies on the association between HLA genotypes and CM-related SJS/TEN with SOC (CM-SJS/TEN with SOC) revealed an association with HLA-A*02:06 in the Japanese; it may be a marker in Koreans. HLA-B*44:03 was associated with the Japanese, Thais, and Indians; in Brazilians of European ancestry, it may be a positive marker. PTGER3 is a susceptibility gene; HLA-A*02:06 and PTGER3 polymorphisms exerted additive effects in Japane

SUBMITTER: Ueta M 

PROVIDER: S-EPMC9309426 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature