Preclinical evaluation of [¹⁸F]FDG-PET as a biomarker of lymphoid tissue disease and inflammation in Zika virus infection.

ABSTRACT:

Purpose

Zika (ZIKV) is a viral inflammatory disease affecting adults, children, and developing fetuses. It is endemic to tropical and sub-tropical countries, resulting in half the global population at risk of infection. Despite this, there are no approved therapies or vaccines against ZIKV disease. Non-invasive imaging biomarkers are potentially valuable tools for studying viral pathogenesis, prognosticating host response to disease, and evaluating in vivo efficacy of experimental therapeutic interventions. In this study, we evaluated [¹⁸F]fluorodeoxyglucose ([¹⁸F]FDG)-positron emission tomography (PET) as an imaging biomarker of ZIKV disease in a mouse model and correlated metabolic tracer tissue uptake with real-time biochemical, virological, and inflammator

SUBMITTER: Victorio CBL 

PROVIDER: S-EPMC9309455 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature