Baseline Testosterone Predicts Body Composition and Metabolic Response to Testosterone Therapy.

ABSTRACT:

Context

Male hypogonadism adversely affects body composition, bone mineral density (BMD), and metabolic health. A previous report showed that pre-treatment testosterone (T) levels of <200 ng/dl is associated with greater improvement in spine BMD with T therapy. However, to date, there is no study that investigates whether baseline T levels also influence body composition and metabolic response to T therapy.

Objective

The aim of this study is to determine if there are differences in the changes in body composition, metabolic profile, and bone turnover markers, in addition to BMD, in response to T therapy in men with a baseline T level of <264 ng/dl compared to those with levels ≥264 ng/dl.

Methods

This is a secondary analysis of a single-arm, open-label clinical trial

SUBMITTER: Deepika F 

PROVIDER: S-EPMC9309506 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature