Dataset Information

Whole-Genome Sequencing and Genomic Variant Analysis of Kazakh Individuals.

ABSTRACT: Kazakhstan, the ninth-largest country in the world, is located along the Great Silk Road and connects Europe with Asia. Historically, its territory has been inhabited by nomadic tribes, and modern-day Kazakhstan is a multiethnic country with a dominant Kazakh population. We sequenced and analyzed the genomes of five ethnic Kazakhs at high coverage using the Illumina HiSeq2000 next-generation sequencing platform. The five Kazakhs yielded a total number of base pairs ranging from 87,308,581,400 to 107,526,741,301. On average, 99.06% were properly mapped. Based on the Het/Hom and Ti/Tv ratios, the quality of the genomic data ranged from 1.35 to 1.49 and from 2.07 to 2.08, respectively. Genetic variants were identified and annotated. Functional analysis of the genetic variants identified several variants that were associated with higher risks of metabolic and neurogenerative diseases. The present study showed high levels of genetic admixture of Kazakhs that were comparable to those of other Central Asians. These whole-genome sequence data of healthy Kazakhs could contribute significantly to biomedical studies of common diseases as their findings could allow better insight into the genotype-phenotype relations at the population level.

SUBMITTER: Kairov U

PROVIDER: S-EPMC9309552 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Whole-Genome Sequencing and Genomic Variant Analysis of Kazakh Individuals.

Kairov Ulykbek U Molkenov Askhat A Sharip Aigul A Rakhimova Saule S Seidualy Madina M Rhie Arang A Kozhamkulov Ulan U Zhabagin Maxat M Kim Jong-Il JI Lee Joseph H JH Terwilliger Joseph D JD Seo Jeong-Sun JS Zhumadilov Zhaxybay Z Akilzhanova Ainur A

Frontiers in genetics 20220711

Kazakhstan, the ninth-largest country in the world, is located along the Great Silk Road and connects Europe with Asia. Historically, its territory has been inhabited by nomadic tribes, and modern-day Kazakhstan is a multiethnic country with a dominant Kazakh population. We sequenced and analyzed the genomes of five ethnic Kazakhs at high coverage using the Illumina HiSeq2000 next-generation sequencing platform. The five Kazakhs yielded a total number of base pairs ranging from 87,308,581,400 to ...[more]

PMID: 35899193

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Dataset Information

Whole-Genome Sequencing and Genomic Variant Analysis of Kazakh Individuals.

Publications

Whole-Genome Sequencing and Genomic Variant Analysis of Kazakh Individuals.

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