Prefrontal Dopaminergic Regulation of Cue-Guided Risky Decision-Making Performance in Rats.

ABSTRACT: Risky decision-making is the decision made by individuals when they know the probability of each outcome. In order to survive in unpredictable environments, it is necessary for individuals to assess the probability of events occurring to an make appropriate decisions. There are few studies on the neural basis of risky decision-making behavior guided by external cues, which is related to the relative paucity of animal behavioral paradigms. Previous studies have shown that the prefrontal cortex (PFC) plays a key role in risk-based decision-making. The PFC receives projections from the dopamine (DA) system from the ventral tegmental area of the midbrain. The mesocorticolimbic DA system regulates the judgments of reward and value in decision-making. However, the specific receptor mechanism for

SUBMITTER: Yang M 

PROVIDER: S-EPMC9309612 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature