Characterizing the extracellular matrix transcriptome of cervical, endometrial, and uterine cancers.

ABSTRACT: Increasingly, the matrisome, a set of proteins that form the core of the extracellular matrix (ECM) or are closely associated with it, has been demonstrated to play a key role in tumor progression. However, in the context of gynecological cancers, the matrisome has not been well characterized. A holistic, yet targeted, exploration of the tumor microenvironment is critical for better understanding the progression of gynecological cancers, identifying key biomarkers for cancer progression, establishing the role of gene expression in patient survival, and for assisting in the development of new targeted therapies. In this work, we explored the matrisome gene expression profiles of cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), uterine corpus endometrial carcinoma (UC

SUBMITTER: Cook CJ 

PROVIDER: S-EPMC9309672 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature