Effect of Tanshinone IIA on Gut Microbiome in Diabetes-Induced Cognitive Impairment.

ABSTRACT: Diabetes-induced cognitive impairment (DCI) presents a major public health risk among the aging population. Previous clinical attempts on known therapeutic targets for DCI, such as depleted insulin secretion, insulin resistance, and hyperglycaemia have delivered poor patient outcomes. However, recent evidence has demonstrated that the gut microbiome plays an important role in DCI by modulating cognitive function through the gut-brain crosstalk. The bioactive compound tanshinone IIA (TAN) has shown to improve cognitive and memory function in diabetes mellitus models, though the pharmacological actions are not fully understood. This study aims to investigate the effect and underlying mechanism of TAN in attenuating DCI in relation to regulating the gut microbiome. Metagenomic sequencing anal

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC9309808 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature