Peroxisomal Proliferator-Activated Receptor β/δ Deficiency Induces Cognitive Alterations.

ABSTRACT: Peroxisome proliferator-activated receptor β/δ (PPARβ/δ), the most PPAR abundant isotype in the central nervous system, is involved in microglial homeostasis and metabolism, whose disturbances have been demonstrated to play a key role in memory impairment. Although PPARβ/δ function is well-established in metabolism, its contribution to neuronal and specifically memory process is underexplored. Therefore, the aim of the study is to determine the role of PPARβ/δ in the neuropathological pathways involved in memory impairment and as to whether a risk factor implicated in memory loss such as obesity modulates neuropathological markers. To carry out this study, 6-month-old total knock-out for the Ppard gene male mice with C57BL/6X129/SV background (PPARβ/δ^-/-) an

SUBMITTER: Espinosa-Jimenez T 

PROVIDER: S-EPMC9310104 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature