Effects of camphor and related compounds on slowly adapting mechanoreceptors in the rat sinus hair follicle.

ABSTRACT:

Introduction

Camphor is a popular compound for therapeutic and cosmetic use with a distinctive odour, and somatosensory warming and cooling properties. The mechanisms for its action remain unclear.

Objective

The current study examined the effects of two enantiomers of camphor and related monoterpenoid compounds on mechanoreceptors.

Methods

Extracellular recordings were made in an in vitro bath preparation. Camphor, borneol, eugenol, carveol, and thymol were tested on the neural activity of St I and St II slowly adapting mechanoreceptors in the rat vibrissal hair follicle preparation.

Results

All compounds tested (0.5 - 2 mM bath concentrations) resulted in dose-dependent depression of spontaneous and mechanically evoked firing (dynamic and static phases)

SUBMITTER: Cahusac PMB 

PROVIDER: S-EPMC9310123 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature