Endothelial TrkA coordinates vascularization and innervation in thermogenic adipose tissue and can be targeted to control metabolism.

ABSTRACT:

Objective

Brown adipogenesis and thermogenesis in brown and beige adipose tissue (AT) involve vascular remodeling and sympathetic neuronal guidance. Here, we investigated the molecular mechanism coordinating these processes.

Methods

We used mouse models to identify the molecular target of a peptide CPATAERPC homing to the endothelium of brown and beige AT.

Results

We demonstrate that CPATAERPC mimics nerve growth factor (NGF) and identify a low molecular weight isoform of NGF receptor, TrkA, as the CPATAERPC cell surface target. We show that the expression of truncated endothelial TrkA is selective for brown and subcutaneous AT. Analysis of mice with endothelium-specific TrkA knockout revealed the role of TrkA in neuro-vascular coordination supporting the thermogenic

SUBMITTER: Daquinag AC 

PROVIDER: S-EPMC9310128 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature