Molecular and Clinical Characterization of Human Adenovirus E4-Associated Conjunctivitis.

ABSTRACT:

Purpose

To determine the characteristics of conjunctivitis associated with human adenovirus E4 (AdV E4).

Methods

Samples and outcomes from 500 patients with conjunctivitis were obtained from the NVC-422 randomized controlled clinical trial comparing auriclosene to placebo. Molecular typing identified 36 cases associated with AdV E4. Signs and symptoms at presentation and at the day 18 endpoint were compared with the larger cohort of 262 subjects with conjunctivitis caused by due to AdV D8. Full viral genomes of 22 AdV E4 isolates were reconstructed.

Results

AdV E4 was the most frequently identified adenoviral type in conjunctivitis cases from the United States. Signs and symptoms at presentation were comparable to those associated with AdV D8. Viral load at presentati

SUBMITTER: Van Gelder RN 

PROVIDER: S-EPMC9310136 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature