Birth Weight and Risk of Childhood Acute Lymphoblastic Leukemia in Arizona, Illinois, and Kentucky.

ABSTRACT:

Objective

To confirm the previously reported increased risk of leukemia among macrosomic children (those with birth weight >4 kg).

Methods

Birth certificates of Arizona, Illinois, and Kentucky children diagnosed as having acute lymphoblastic leukemia (ALL) before age 5 years were matched with birth certificates from leukemia-free children of the same sex, race, and ethnicity who were born in the same county on or about the same day. Odds ratios (ORs) for ALL among children of low (<2.5 kg) or high (>4 kg) birth weight were calculated by conditional logistic regression.

Results

Children with high birth weight had an elevated risk of ALL in the first 5 years of life (OR 1.28, 95% confidence interval [CI] 1.01-1.61). The excess risk was confined to non-Hispanic whites (O

SUBMITTER: Groves FD 

PROVIDER: S-EPMC9310147 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature