Understanding the role of sex on outcomes for the cancer patient undergoing treatment with immune checkpoint inhibitors: a scoping review protocol.

ABSTRACT:

Introduction

Immune checkpoint inhibitors (ICIs) have changed the treatment landscape for multiple cancer types. Sex plays an important role in both the development of cancer as well as the functioning of the immune system. Though a difference in response to immune therapy is emerging between men and women it is unclear how this difference affects cancer outcomes and what the potential underlying mechanisms are for those effects. The objective of this study is to describe the influence that sex has on the outcomes experienced by cancer patients on ICI therapy and to identify and analyse any knowledge gaps in the field.

Method and analysis

The framework for this methodology was guided by the Joanna Briggs Institute Manual for Evidence Synthesis. The search and review will be

SUBMITTER: Shaver AL 

PROVIDER: S-EPMC9310149 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature