Differences and similarities between familial and sporadic frontotemporal dementia: An Italian single-center cohort study.

ABSTRACT:

Introduction

The possibility to generalize our understandings on treatments and assessments to both familial frontotemporal dementia (f-FTD) and sporadic FTD (s-FTD) is a fundamental perspective for the near future, considering the constant advancement in potential disease-modifying therapies that target particular genetic forms of FTD. We aimed to investigate differences in clinical features, cerebrospinal fluid (CSF), and blood-based biomarkers between f-FTD and s-FTD.

Methods

In this longitudinal cohort study, we evaluated a consecutive sample of symptomatic FTD patients, classified as f-FTD and s-FTD according to Goldman scores (GS). All patients underwent clinical, behavioral, and neuropsychiatric symptom assessment, CSF biomarkers and serum neurofilament light (NfL) an

SUBMITTER: Benussi A 

PROVIDER: S-EPMC9310192 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature