Positive effect of immunomodulatory therapies on disease progression in Huntington's disease? Data from a real-world cohort.

ABSTRACT:

Background

The role of neuroinflammation and autoimmune processes in neurodegenerative diseases is not fully understood. Activation of microglia with expression of proinflammatory cytokines supports the hypothesis that immune processes may play an important role in the pathophysiology of Huntington's disease (HD) and thus, immunomodulating therapies might have potential neuroprotective properties. Until now, no disease-modifying therapy (DMT) is available for HD.

Objective

The aim of this research was to characterize a cohort of patients suffering from both HD and autoimmune demyelinating diseases of the central nervous system (classified as G35-37 in ICD-10; ADD-CNS) in comparison to HD cases without ADD-CNS. In particular, we were interested to investigate potential modula

SUBMITTER: Achenbach J 

PROVIDER: S-EPMC9310279 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature