Association of multiple sclerosis with mortality in sepsis: a population-level analysis.

ABSTRACT:

Background

Multiple sclerosis (MS) is associated with increased risk of sepsis and higher sepsis-related mortality, compared to the general population. However, the evidence on the prognostic impact of MS in sepsis has been scarce. We aimed to evaluate the population-level association of MS with short-term mortality in sepsis.

Methods

We performed a retrospective population-based cohort study using a statewide data set to identify hospitalizations aged ≥ 18 years in Texas with sepsis, with and without MS during 2010-2017. Multilevel logistic models were fit to estimate the association of MS with short-term mortality among all sepsis hospitalizations, and for sensitivity analyses among hospitalizations with septic shock and those admitted to ICU.

Results

Among 283,025

SUBMITTER: Oud L 

PROVIDER: S-EPMC9310428 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature