Aged microglia promote peripheral T cell infiltration by reprogramming the microenvironment of neurogenic niches.

ABSTRACT:

Background

The immune cell compartment of the mammalian brain changes dramatically and peripheral T cells infiltrate the brain parenchyma during normal aging. However, the mechanisms underlying age-related T cell infiltration in the central nervous system remain unclear.

Results

Chronic inflammation and peripheral T cell infiltration were observed in the subventricular zone of aged mice. Cell-cell interaction analysis revealed that aged microglia released CCL3 to recruit peripheral CD8⁺ memory T cells. Moreover, the aged microglia shifted towards a pro-inflammation state and released TNF-α to upregulate the expression of VCAM1 and ICAM1 in brain venous endothelial cells, which promoted the transendothelial migration of peripheral T cells. In vitro experiment revea

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9310471 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature