STAT3-mediated osteogenesis and osteoclastogenesis in osteoporosis.

ABSTRACT: Osteoporosis is a common skeletal disease with marked bone loss, deterioration of the bone microstructure and bone fragility. An abnormal bone remodelling cycle with relatively increased bone resorption is the crucial pathophysiological mechanism. Bone remodelling is predominantly controlled by osteoblasts and osteoclasts, which are specialized cell types that are regulated by a variety of osteogenic and osteoclastic factors, including cytokines expressed within the bone microenvironment under local or systemic inflammatory conditions. Signal transducer and activator of transcription 3 (STAT3) plays a prominent role in the communication between cytokines and kinases by binding downstream gene promotors and is involved in a wide range of biological or pathological processes. Emerging eviden

SUBMITTER: Hou X 

PROVIDER: S-EPMC9310501 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature