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Anti-nucleocapsid antibody levels and pulmonary comorbid conditions are linked to post-COVID-19 syndrome.

ABSTRACT: BACKGROUNDProlonged symptoms after SARS-CoV-2 infection are well documented. However, which factors influence development of long-term symptoms, how symptoms vary across ethnic groups, and whether long-term symptoms correlate with biomarkers are points that remain elusive.METHODSAdult SARS-CoV-2 reverse transcription PCR-positive (RT-PCR-positive) patients were recruited at Stanford from March 2020 to February 2021. Study participants were seen for in-person visits at diagnosis and every 1-3 months for up to 1 year after diagnosis; they completed symptom surveys and underwent blood draws and nasal swab collections at each visit.RESULTSOur cohort (n = 617) ranged from asymptomatic to critical COVID-19 infections. In total, 40% of participants reported at least 1 symptom associated with COVID-19 six months after diagnosis. Median time from diagnosis to first resolution of all symptoms was 44 days; median time from diagnosis to sustained symptom resolution with no recurring symptoms for 1 month or longer was 214 days. Anti-nucleocapsid IgG level in the first week after positive RT-PCR test and history of lung disease were associated with time to sustained symptom resolution. COVID-19 disease severity, ethnicity, age, sex, and remdesivir use did not affect time to sustained symptom resolution.CONCLUSIONWe found that all disease severities had a similar risk of developing post-COVID-19 syndrome in an ethnically diverse population. Comorbid lung disease and lower levels of initial IgG response to SARS-CoV-2 nucleocapsid antigen were associated with longer symptom duration.TRIAL REGISTRATIONClinicalTrials.gov, NCT04373148.FUNDINGNIH UL1TR003142 CTSA grant, NIH U54CA260517 grant, NIEHS R21 ES03304901, Sean N Parker Center for Allergy and Asthma Research at Stanford University, Chan Zuckerberg Biohub, Chan Zuckerberg Initiative, Sunshine Foundation, Crown Foundation, and Parker Foundation.

SUBMITTER: Jia X

PROVIDER: S-EPMC9310538 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Anti-nucleocapsid antibody levels and pulmonary comorbid conditions are linked to post-COVID-19 syndrome.

Jia Xiaolin X Cao Shu S Lee Alexandra S AS Manohar Monali M Sindher Sayantani B SB Ahuja Neera N Artandi Maja M Blish Catherine A CA Blomkalns Andra L AL Chang Iris I Collins William J WJ Desai Manisha M Din Hena Naz HN Do Evan E Fernandes Andrea A Geng Linda N LN Rosenberg-Hasson Yael Y Mahoney Megan Ruth MR Glascock Abigail L AL Chan Lienna Y LY Fong Sharon Y SY Phelps Maira M Raeber Olivia O Purington Natasha N Röltgen Katharina K Rogers Angela J AJ Snow Theo T Wang Taia T TT Solis Daniel D Vaughan Laura L Verghese Michelle M Maecker Holden H Wittman Richard R Puri Rajan R Kistler Amy A Yang Samuel S Boyd Scott D SD Pinsky Benjamin A BA Chinthrajah Sharon S Nadeau Kari C KC

JCI insight 20220708 13

BACKGROUNDProlonged symptoms after SARS-CoV-2 infection are well documented. However, which factors influence development of long-term symptoms, how symptoms vary across ethnic groups, and whether long-term symptoms correlate with biomarkers are points that remain elusive.METHODSAdult SARS-CoV-2 reverse transcription PCR-positive (RT-PCR-positive) patients were recruited at Stanford from March 2020 to February 2021. Study participants were seen for in-person visits at diagnosis and every 1-3 mon ...[more]

PMID: 35801588

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Anti-nucleocapsid antibody levels and pulmonary comorbid conditions are linked to post-COVID-19 syndrome.

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Anti-nucleocapsid antibody levels and pulmonary comorbid conditions are linked to post-COVID-19 syndrome.

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