Parallel evolution of two distinct lymphoid proliferations in clonal haematopoiesis.

ABSTRACT:

Aims

Angioimmunoblastic T-cell lymphoma (AITL) is genetically characterized by TET2 and DNMT3A mutations occurring in haematopoietic progenitor cells, and late events (e.g. the RHOA-G17V mutation) associated with malignant transformation. As TET2/DNMT3A-mutated progenitor cells can differentiate into multilineage progenies and give rise to both AITL and myeloid neoplasms, they may also have the potential to lead to other metachronous/synchronous neoplasms. We report two cases showing parallel evolution of two distinct potentially neoplastic lymphoid proliferations from a common mutated haematopoietic progenitor cell population.

Methods and results

Both cases presented with generalized lymphadenopathy. In case 1 (a 67-year-old female), an initial lymph node (LN) biopsy was di

SUBMITTER: Attygalle AD 

PROVIDER: S-EPMC9310594 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature