Organoplatinum Compounds as Anion-Tuneable Uphill Hydroxide Transporters.

ABSTRACT: Active transport of ions uphill, creating a concentration gradient across a cell membrane, is essential for life. It remains a significant challenge to develop synthetic systems that allow active uphill transport. Here, a transport process fuelled by organometallic compounds is reported that creates a pH gradient. The hydrolysis reaction of Pt^II complexes results in the formation of aqua complexes that established rapid transmembrane movement ("flip-flop") of neutral Pt-OH species, leading to protonation of the OH group in the inner leaflet, generating OH^- ions, and so increasing the pH in the intravesicular solution. The organoplatinum complex effectively transports bound hydroxide ions across the membrane in a neutral complex. The initial net flow of the Pt^II</

SUBMITTER: Chen LJ 

PROVIDER: S-EPMC9310596 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature