Impact of starting BMI and degree of weight loss on changes in appetite-regulating hormones during diet-induced weight loss.

ABSTRACT:

Objective

The aim of this study was to determine whether the hormone changes following weight loss are proportional to the degree of weight loss and to starting BMI.

Methods

A very low-energy diet was used to achieve 15% weight loss. Fasting and postprandial gut hormones and leptin were measured during a meal test at baseline and at 5% (1%), 10% (2%), and 15% (2.5%) weight loss. Linear mixed-effects models were used to analyze hormone changes.

Results

From baseline to 5% weight loss, decreases were seen in fasting concentrations of leptin (-8.25 ng/mL; p < 0.001), amylin (-21.3 pg/mL; p < 0.001), and glucagon-like peptide 1 (-59.55 pg/mL; p < 0.001). There was a small further reduction in leptin between 5% and 15% weight loss (-1.88 ng/mL; p = 0.019) but not in glucag

SUBMITTER: Edwards KL 

PROVIDER: S-EPMC9310603 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature