Muscle hypertrophic effect of inhaled beta₂ -agonist is associated with augmented insulin-stimulated whole-body glucose disposal in young men.

ABSTRACT: Rodent studies highlight enhancement of glucose tolerance and insulin sensitivity as potential clinically relevant effects of chronic beta₂ -agonist treatment. However, the doses administered to rodents are not comparable with the therapeutic doses used for humans. Thus, we investigated the physiological effects of prolonged beta₂ -agonist treatment at inhaled doses resembling those used in respiratory diseases on insulin-stimulated whole-body glucose disposal and putative mechanisms in skeletal muscle and adipose tissue of healthy men. Utilizing a randomized placebo-controlled parallel-group design, we assigned 21 healthy men to 4 weeks daily inhalation of terbutaline (TER; 4 mg × day^-1 , n = 13) or placebo (PLA, n = 8). Before and after treatments, we ass

SUBMITTER: Jessen S 

PROVIDER: S-EPMC9310637 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature