Caffeine Consumption and Dementia: Are Lewy Bodies the Link?

ABSTRACT:

Objective

The objective of this study was to examine the association between caffeine intake and cognitive impairment. Caffeine-neuropathology correlations and interactions with lifestyle and genetic factors impacting caffeine metabolism and response were also tested.

Methods

We included 888 participants aged 59+ years from the Rush Memory and Aging Project (MAP) and 303,887 participants aged 55+ years from the UK Biobank (UKB). MAP participants took part in annual cognitive testing. Diagnosis of dementia was based on clinical neurological examination and standardized criteria. A subset provided postmortem tissue for neuropathologic evaluation for common age-related diseases (eg, Alzheimer's disease [AD], Lewy bodies, and vascular). For UKB, dementia was determined by linked

SUBMITTER: Cornelis MC 

PROVIDER: S-EPMC9310711 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature