A Selective Adenylyl Cyclase 1 Inhibitor Relieves Pain Without Causing Tolerance.

ABSTRACT: Among the ten different adenylyl cyclase isoforms, studies with knockout animals indicate that inhibition of AC1 can relieve pain and reduce behaviors linked to opioid dependence. We previously identified ST034307 as a selective inhibitor of AC1. The development of an AC1-selective inhibitor now provides the opportunity to further study the therapeutic potential of inhibiting this protein in pre-clinical animal models of pain and related adverse reactions. In the present study we have shown that ST034307 relives pain in mouse models of formalin-induced inflammatory pain, acid-induced visceral pain, and acid-depressed nesting. In addition, ST034307 did not cause analgesic tolerance after chronic dosing. We were unable to detect ST034307 in mouse brain following subcutaneous injections but s

SUBMITTER: Giacoletti G 

PROVIDER: S-EPMC9310748 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature