Bone health, intellectual disability and epilepsy: An observational community-based study.

ABSTRACT:

Objectives

Intellectual disability (ID) and epilepsy are independent risk factors for osteoporosis. Diverse predisposing factors influence this, for example in ID, genetics and poor nutrition and in epilepsy, anti-seizure medication (ASM). Around 25% people with ID have epilepsy, majority treatment resistant. ASMs polypharmacy is common. However, little is known about the bone-related characteristics of this vulnerable group. A prospective observational cohort study of bone profile across a community ID Epilepsy service was undertaken to understand this.

Materials & methods

Participants were on minimum 2 years of ASMs. Baseline demographics, epilepsy data, bone metabolism biomarkers, bone mineral density (BMD) and vitamin D levels were collected. Doses needed to correct vita

SUBMITTER: Winterhalder R 

PROVIDER: S-EPMC9310839 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature