Spinal cord gray matter atrophy is associated with functional decline in post-polio syndrome.

ABSTRACT:

Objective

To determine if patients with post-polio syndrome (PPS) show spinal cord gray matter (SCGM) atrophy and to assess associations between SCGM atrophy, muscle strength and patient-reported functional decline.

Methods

Twenty patients diagnosed with PPS (March of Dimes criteria) and 20 age- and sex-matched healthy controls (HC) underwent 3T axial 2D-rAMIRA magnetic resonance imaging at the intervertebral disc levels C2/C3-C6/C7, T9/T10 and the lumbar enlargement level (T_max ) (0.5 × 0.5 mm² in-plane resolution). SCGM areas were segmented manually by two independent raters. Muscle strength, self-reported fatigue, depression and pain measures were assessed.

Results

Post-polio syndrome patients showed significantly and preferentially reduced SC

SUBMITTER: Wendebourg MJ 

PROVIDER: S-EPMC9310958 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature