Anticonvulsive properties of soticlestat, a novel cholesterol 24-hydroxylase inhibitor.

ABSTRACT:

Objective

The formation of 24S-hydroxycholesterol is a brain-specific mechanism of cholesterol catabolism catalyzed by cholesterol 24-hydroxylase (CYP46A1, also known as CH24H). CH24H has been implicated in various biological mechanisms, whereas pharmacological lowering of 24S-hydroxycholesterol has not been fully studied. Soticlestat is a novel small-molecule inhibitor of CH24H. Its therapeutic potential was previously identified in a mouse model with an epileptic phenotype. In the present study, the anticonvulsive property of soticlestat was characterized in rodent models of epilepsy that have long been used to identify antiseizure medications.

Methods

The anticonvulsive property of soticlestat was investigated in maximal electroshock seizures (MES), pentylenetetrazol (PTZ

SUBMITTER: Nishi T 

PROVIDER: S-EPMC9311151 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature