Is acid suppression associated with the increased length of stay in diabetic ketoacidosis patients? A nationwide analysis.

ABSTRACT:

Background

Diabetic ketoacidosis (DKA) patients present with low serum bicarbonate ( HCO3-${\rm{HCO}}_{3}^{-} $ ), and an increase in its level to ≥15 mEq/L is considered one of the criteria for DKA resolution. Both proton pump inhibitors and histamine-2 receptor antagonists inhibit downstream functioning of H⁺ /K⁺ ATPase in the gastric parietal cells, which results in the decreased secretion of HCO3-${\rm{HCO}}_{3}^{-} $ into the bloodstream.

Objectives

We aimed to introduce the hypothesis that DKA patients on acid-suppressive medications may have a delayed rise in serum HCO3-${\rm{HCO}}_{3}^{-} $ to >15 mEq/L that may cause increased hospital length of stay (LOS) and sought to compare the outcomes of such patients. For the sake of simplicity, conditio

SUBMITTER: Farooq U 

PROVIDER: S-EPMC9311185 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature