Identification of novel prostate cancer genes in patients stratified by Gleason classification: Role of antitumoral genes.

ABSTRACT: Prostate cancer (PCa) is a tumor with a great heterogeneity, both at a molecular and clinical level. Despite its global good prognosis, cases can vary from indolent to lethal metastatic and scientific efforts are aimed to discern those with worse outcomes. Current prognostic markers, as Gleason score, fall short when it comes to distinguishing these cases. Identification of new early biomarkers to enable a better PCa distinction and classification remains a challenge. In order to identify new genes implicated in PCa progression we conducted several differential gene expression analyses over paired samples comparing primary PCa tissue against healthy prostatic tissue of PCa patients. The results obtained show that this approach is a serious alternative to overcome patient heterogeneity. We

SUBMITTER: Diaz de la Guardia-Bolivar E 

PROVIDER: S-EPMC9311191 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature